Careers

Company Profile

Cybrexa is developing a new generation of small molecule cancer therapeutics which are directly targeted to the tumor microenvironment using a novel peptide-based technology developed by an internationally recognized research laboratory at Yale. The scientific co-founders are physician-scientists at Yale with extensive expertise in DNA repair, chemo/radiosensitizer development, translational research, and Phase I/II clinical trials in oncology. This venture is backed by investors with extensive experience in the biotechnology sector who have launched companies that have generated exit value in excess of $1 billion. We are a teamwork-driven, dynamic and energetic group, and we seek an individual for this position who shares our core philosophy of innovative, relentless and milestone-driven drug development.

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We are currently hiring for the following positions:

Biology Director

Cybrexa is seeking a self-motivated, energetic and creative biologist with hands-on experience in oncology & immunology, to take part in the development of novel therapeutics in oncology and reporting to the Chief Scientific Officer.  This person will play a key role in the development of our scientific strategy, as well as managing the day to day biology operations. This role will span the key functions of managing in-house biology FTEs as well as biology FTEs that have been outsourced at key CROs.

Essential Job Functions and Duties

  • Lead the company’s biology operations to meet company goals and ensure productivity.
  • Lead the technical biology team and have the opportunity to make significant and high impact contributions in a dynamic small group setting on drug discovery programs.

 Knowledge, Skills and Abilities

  • Understanding of the oncology therapeutics area.
  • Assume responsibility for direct reports as needed including recruiting, managing, mentoring and developing scientific staff.
  • Contribute to and implement an overall drug development strategy to support nonclinical and early clinical pharmacology development during all stages of drug development.
  • Manage or lead projects for multiple programs across the portfolio and schedule activities in accordance with line function and company goals, assignments and priorities.
  • Effectively manage both internal and external work, including interactions with technical and administrative staff at CROs or external vendors to deliver high quality results

 Education/Experience

Candidate will be required to have Doctorate (Ph.D.) in pharmacology, or a related, relevant discipline & Nonclinical pharmacology background and 5+ years of experience in the pharmaceutical, CRO, and/or biotechnology field at a Scientist level.

Experience with the preparation of regulatory submissions (IND/CTDs, NDA/BLA, etc.) preferred.

Scientist, Biology and Analytical Chemistry

We are seeking an Analytical Chemist for Small Molecule Assay Development and Analysis.

Essential Job Functions and Duties

The successful candidate will develop HPLC and mass spectrometry assays, analyze samples and interpret results for analytical development and characterization of small molecule, some containing protein and other excipients, to support the profiling of new drug and early stage formulation development activities. In addition, the candidate’s ability to perform and work with pharmacology scientists will be beneficial. The Candidate should have extensive experience the design of pre-clinical studies. The Candidate responsibilities will include the following work:

Knowledge, Skills and Abilities

  • Establish protocols for in vitro experiments, collaborate with colleagues and perform analytical testing of candidate compounds
  • Apply scientific expertise and drug discovery experience to impact existing and future new drug candidate identification
  • Maintain a ‘cutting edge’ awareness of technical developments and scientific knowledge.
  • Conduct studies to increase confidence in rationale for new approaches, and hence support new idea generation and clinical proof of concept studies.
  • Provide in vitro experimental support
  • Ability to perform/assist in in vivo pharmacology experiments would be preferred but not required
  • Prepare written reports and present scientific data at appropriate scientific meetings (internal and external).

Education/Experience

The candidate should have at least a BS/MS degree in biology with at least 2 years of experience of industry experience in biological sciences or biochemistry, with demonstrated scientific excellence. Previous experience in working on drug discovery programs to develop compounds from the pre-clinical to the clinical setting would be preferred but not required.

Senior Scientist-Biology, In Vivo Histologist

Cybrexa is seeking a self-motivated, energetic and creative biologist with hands-on experience in oncology & immunology, to take part in the development of novel therapeutics in oncology and reporting to the biology manager.

 Essential Job Functions and Duties

 As a Research Histologist/ Scientist, this position will provide technical immuno-histochemistry (IHC) support for the development and characterization of small moleculesand peptides to the team.  The role will be laboratory based, working within the in vivopharmacology team to support the evaluation of pre-clinical pharmacology studies.  This will involve using IHC to characterize mouse tumor models and evaluate bio-marker and efficacy responses following therapeutic drug testing. The candidate will also play a role in supporting our immuno-phenotyping capabilities for mouse tumor models of cancer, including developing multiplex IHC assays, and fluorescence applications. The Candidate should have extensive experience in performing pharmacology experiments to aid in the design of pre-clinical studies. Additional responsibilities will include the following work:

Knowledge, Skills and Abilities

  • Apply scientific expertise and drug discovery experience to impact existing and future new drug candidate development
  • Maintain a ‘cutting edge’ awareness of technical developments and scientific knowledge.
  • Conduct studies to increase confidence in rationale for new approaches, and hence support new idea generation and clinical proof of concept studies.
  • Provide in vivo experimental support
  • Support collaborative, translational pharmacology and PKPD initiatives.
  • Prepare written reports and present scientific data at appropriate scientific meetings (internal and external).

Education/Experience

The candidate should have at least a BS/MS degree with 5+ years of industry experience in biological sciences or biochemistry, with demonstrated scientific excellence. Previous experience in working drug discovery programs to develop compounds from the pre-clinical to the clinical setting would be preferred but not required.

Director, Strategic Marketing – Cybrexa Therapeutics

Cybrexa is seeking a Director, Strategic Marketing to play a leadership role in executing our business and product development strategy including strategic growth opportunities, which may include alliances, partnerships, and M&A.  This role will span the key functions of strategic marketing, business development and commercial market assessment and will report directly to the CEO.

Essential Job Functions and Duties

  • Evaluate commercial opportunities for the company’s products and provide marketing/ commercial input based on disease/epidemiological and market data.
  • Work closely with the development team to perform market analysis for the company’s pipeline products and establish the value proposition to make Go/No-Go decisions for development.
  • Maintain detailed knowledge of the external market environment of the oncology therapeutics industry that impact on areas of interest to the company including competition, regulatory, reimbursement and medical/clinical environments.
  • Direct market research initiatives in support of launch strategies to better understand market landscape including competitor analysis
  • Develop and maintain relationships with national and regional key opinion leaders
  • Develop promotional and other collateral materials needed to support business development initiatives and efforts

Knowledge, Skills and Abilities

  • Understanding of the oncology therapeutics market and competitive environment, including deal activity and potential opportunities, is essential.
  • Strong business acumen with the ability to evaluate deal alternatives as it relates to potential alliances and partnerships
  • Excellent communication and interpersonal skills.
  • Experience working in a highly dynamic environment and the ability to effectively deal with change.
  • Advanced scientific degree attractive, with at least 15+ years of relevant industry experience in biotech/pharma; additional finance degree (e.g., MBA) is a plus
  • Oncology knowledge required.

This position will be based in the Company’s New Haven, CT headquarters but will require travel as the needs of the business dictate.

5 Science Park 395 Winchester Ave. New Haven, CT 06511 (860) 717-2731